B Cell Immunity in Lung Transplant Rejection - Effector Mechanisms and Therapeutic Implications

B Cell Immunity in Lung Transplant Rejection - Effector Mechanisms and Therapeutic Implications

Blog Article

Allograft rejection remains the major hurdle in lung transplantation despite modern immunosuppressive treatment.As part of the alloreactive process, B cells are increasingly recognized as modulators of alloimmunity and initiators of a donor-specific humoral response.In chronically rejected lung allografts, B CHOLESTOLESS cells contribute to the formation of tertiary lymphoid structures and promote local alloimmune responses.However, B cells are functionally heterogeneous and some B cell subsets may promote alloimmune tolerance.In this review, we describe the current understanding of B-cell-dependent mechanisms in pulmonary allograft rejection and highlight promising future strategies 350 that employ B cell-targeted therapies.